8 research outputs found
A model of brain morphological changes related to aging and Alzheimer's disease from cross-sectional assessments
In this study we propose a deformation-based framework to jointly model the
influence of aging and Alzheimer's disease (AD) on the brain morphological
evolution. Our approach combines a spatio-temporal description of both
processes into a generative model. A reference morphology is deformed along
specific trajectories to match subject specific morphologies. It is used to
define two imaging progression markers: 1) a morphological age and 2) a disease
score. These markers can be computed locally in any brain region. The approach
is evaluated on brain structural magnetic resonance images (MRI) from the ADNI
database. The generative model is first estimated on a control population,
then, for each subject, the markers are computed for each acquisition. The
longitudinal evolution of these markers is then studied in relation with the
clinical diagnosis of the subjects and used to generate possible morphological
evolution. In the model, the morphological changes associated with normal aging
are mainly found around the ventricles, while the Alzheimer's disease specific
changes are more located in the temporal lobe and the hippocampal area. The
statistical analysis of these markers highlights differences between clinical
conditions even though the inter-subject variability is quiet high. In this
context, the model can be used to generate plausible morphological trajectories
associated with the disease. Our method gives two interpretable scalar imaging
biomarkers assessing the effects of aging and disease on brain morphology at
the individual and population level. These markers confirm an acceleration of
apparent aging for Alzheimer's subjects and can help discriminate clinical
conditions even in prodromal stages. More generally, the joint modeling of
normal and pathological evolutions shows promising results to describe
age-related brain diseases over long time scales.Comment: NeuroImage, Elsevier, In pres
Deep neural networks for fast acquisition of aortic 3D pressure and velocity flow fields
Computational fluid dynamics (CFD) can be used to simulate vascular
haemodynamics and analyse potential treatment options. CFD has shown to be
beneficial in improving patient outcomes. However, the implementation of CFD
for routine clinical use is yet to be realised. Barriers for CFD include high
computational resources, specialist experience needed for designing simulation
set-ups, and long processing times. The aim of this study was to explore the
use of machine learning (ML) to replicate conventional aortic CFD with
automatic and fast regression models. Data used to train/test the model
consisted of 3,000 CFD simulations performed on synthetically generated 3D
aortic shapes. These subjects were generated from a statistical shape model
(SSM) built on real patient-specific aortas (N=67). Inference performed on 200
test shapes resulted in average errors of 6.01% +/-3.12 SD and 3.99% +/-0.93 SD
for pressure and velocity, respectively. Our ML-based models performed CFD in
+/-0.075 seconds (4,000x faster than the solver). This proof-of-concept study
shows that results from conventional vascular CFD can be reproduced using ML at
a much faster rate, in an automatic process, and with high accuracy.Comment: 22 pages, 19 figure
Shape-driven deep neural networks for fast acquisition of aortic 3D pressure and velocity flow fields
Computational fluid dynamics (CFD) can be used to simulate vascular haemodynamics and analyse potential treatment options. CFD has shown to be beneficial in improving patient outcomes. However, the implementation of CFD for routine clinical use is yet to be realised. Barriers for CFD include high computational resources, specialist experience needed for designing simulation set-ups, and long processing times. The aim of this study was to explore the use of machine learning (ML) to replicate conventional aortic CFD with automatic and fast regression models. Data used to train/test the model consisted of 3,000 CFD simulations performed on synthetically generated 3D aortic shapes. These subjects were generated from a statistical shape model (SSM) built on real patient-specific aortas (N = 67). Inference performed on 200 test shapes resulted in average errors of 6.01% ±3.12 SD and 3.99% ±0.93 SD for pressure and velocity, respectively. Our ML-based models performed CFD in âŒ0.075 seconds (4,000x faster than the solver). This proof-of-concept study shows that results from conventional vascular CFD can be reproduced using ML at a much faster rate, in an automatic process, and with reasonable accuracy
Voxel-based assessments of treatment effects on longitudinal brain changes in the Multidomain Alzheimer Preventive Trial cohort
International audienceObjective: The Multidomain Alzheimer Preventive Trial (MAPT) was designed to assess the effect of omega-3 supplementation and a multidomain intervention (physical activity, cognitive training and nutritional advice) on cognitive decline of people with subjective memory complaint. In term of cognitive testing, no significant effect on cognitive decline was found over the 3-year follow-up. Yet, in the context of dementia-related conditions, brain morphological changes can be used to foretell the cognitive evolution. In this paper, we evaluate the effect of the interventions on the evolution of the brain morphology using the MR images acquired during MAPT. Methods: Subjects in the MAPT cohort with two MRI acquisitions, at baseline and at 36 months, were included , resulting in a subset of 376 subjects distributed in the 4 intervention groups: multidomain intervention plus omega-3, multidomain intervention plus placebo, omega-3 alone, and placebo alone. The morphological changes were assessed from volume measurements of regions of interest and a voxel-wise deformation-based approach. The primary outcome is the longitudinal deformation observed between the baseline image and the 3-year follow-up. Results: The multi-domain intervention is associated with a significant effect on the 3-year morphological evolution. The effect is similar within the two groups undergoing the intervention regardless of the omega-3 or placebo treatment. The voxel-wise deformation-based approach shows that the differences are mainly located in the left peri-ventricular area next to the temporoparietal junction (TPJ). These morphological changes correspond to a slower morphological evolution and are correlated with a better performance in cognitive assessments. These results could not be observed using the volumetric morphometry approach. No effect of omega-3 was observed.Discussion: In this study, we found that the multidomain intervention has a significant effect on morphological changes that are usually associated with the cognitive decline. This result suggests that effects at the level of cognitive decline may be visible in the long term, and that the cognitive scores may not be powerful enough to detect changes after 3 years. We argue that the use of neuroimaging could help define whether early intervention strategies are effective to delay cognitive decline and dementia
A model of brain morphological changes related to aging and Alzheimer's disease from cross-sectional assessments
International audienceIn this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a generative model. A reference morphology is deformed along specific trajectories to match subject specific morphologies. It is used to define two imaging progression markers: 1) a morphological age and 2) a disease score. These markers can be computed regionally in any brain region. The approach is evaluated on brain structural magnetic resonance images (MRI) from the ADNI database. The model is first estimated on a control population using longitudinal data, then, for each testing subject, the markers are computed cross-sectionally for each acquisition. The longitudinal evolution of these markers is then studied in relation with the clinical diagnosis of the subjects and used to generate possible morphological evolutions. In the model, the morphological changes associated with normal aging are mainly found around the ventricles, while the Alzheimer's disease specific changes are located in the temporal lobe and the hippocampal area. The statistical analysis of these markers highlights differences between clinical conditions even though the inter-subject variability is quite high. The model is also generative since it can be used to simulate plausible morphological trajectories associated with the disease. Our method quantifies two interpretable scalar imaging biomarkers assessing respectively the effects of aging and disease on brain morphology, at the individual and population level. These markers confirm the presence of an accelerated apparent aging component in Alzheimer's patients but they also highlight specific morphological changes that can help discriminate clinical conditions even in prodromal stages. More generally, the joint modeling of normal and pathological evolutions shows promising results to describe age-related brain diseases over long time scales
Shape-driven deep neural networks for fast acquisition of aortic 3D pressure and velocity flow fields.
Computational fluid dynamics (CFD) can be used to simulate vascular haemodynamics and analyse potential treatment options. CFD has shown to be beneficial in improving patient outcomes. However, the implementation of CFD for routine clinical use is yet to be realised. Barriers for CFD include high computational resources, specialist experience needed for designing simulation set-ups, and long processing times. The aim of this study was to explore the use of machine learning (ML) to replicate conventional aortic CFD with automatic and fast regression models. Data used to train/test the model consisted of 3,000 CFD simulations performed on synthetically generated 3D aortic shapes. These subjects were generated from a statistical shape model (SSM) built on real patient-specific aortas (N = 67). Inference performed on 200 test shapes resulted in average errors of 6.01% ±3.12 SD and 3.99% ±0.93 SD for pressure and velocity, respectively. Our ML-based models performed CFD in âŒ0.075 seconds (4,000x faster than the solver). This proof-of-concept study shows that results from conventional vascular CFD can be reproduced using ML at a much faster rate, in an automatic process, and with reasonable accuracy
Voxel based assessments of treatment effects on longitudinal brain changes in the MAPT cohort
International audienceObjective: The Multidomain Alzheimer Preventive Trial (MAPT) was designed to assess the effect of omega-3 supplementation and a multidomain intervention (physical activity, cognitive training and nutritional advice) on cognitive decline of people with subjective memory complaint. In term of cognitive testing, no significant effect on cognitive decline was found over the 3-year follow-up. Yet, in the context of dementia-related conditions, brain morphological changes can be used to foretell the cognitive evolution. In this paper, we evaluate the effect of the interventions on the evolution of the brain morphology using the MR images acquired during MAPT. Methods: Subjects in the MAPT cohort with two MRI acquisitions, at baseline and at 36 months, were included , resulting in a subset of 376 subjects distributed in the 4 intervention groups: multidomain intervention plus omega-3, multidomain intervention plus placebo, omega-3 alone, and placebo alone. The morphological changes were assessed from volume measurements of regions of interest and a voxel-wise deformation-based approach. The primary outcome is the longitudinal deformation observed between the baseline image and the 3-year follow-up. Results: The multi-domain intervention is associated with a significant effect on the 3-year morphological evolution. The effect is similar within the two groups undergoing the intervention regardless of the omega-3 or placebo treatment. The voxel-wise deformation-based approach shows that the differences are mainly located in the left peri-ventricular area next to the temporoparietal junction (TPJ). These morphological changes correspond to a slower morphological evolution and are correlated with a better performance in cognitive assessments. These results could not be observed using the volumetric morphometry approach. No effect of omega-3 was observed.Discussion: In this study, we found that the multidomain intervention has a significant effect on morphological changes that are usually associated with the cognitive decline. This result suggests that effects at the level of cognitive decline may be visible in the long term, and that the cognitive scores may not be powerful enough to detect changes after 3 years. We argue that the use of neuroimaging could help define whether early intervention strategies are effective to delay cognitive decline and dementia